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In the years since, the peptide has accumulated reports of effects on sleep architecture, stress-axis hormones, opioid-system interactions, thermoregulation and pain modulation without any of these effects being mechanistically anchored to a defined molecular target
Joint pain, stiffness, swelling, and reduced mobility often affect sleep, exercise, work, and overall quality of life
Cell 170 , 492506 (2017)
This may mediate activation of perivascular Ms, microglia, and astrocytes, and initiate further immune responses within the brain parenchyma, suggesting neuroinflammation can be triggered by signaling from the periphery, without primary injury or disease originating within the CNS
Progress of microfluidic hydrogel-based scaffolds and organ-on-chips for the cartilage tissue engineering
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